Industry 4.0 has brought the rise of connected devices that stream information and optimize operational behavior over the course of a device’s lifetime. This presentation covers how to develop and deploy MATLAB^® algorithms and Simulink^® models as digital twin and IoT components on assets, edge devices, or cloud for anomaly detection, control optimization, and other applications. It includes an introduction to how assets, edge, and OT/IT components are connected. The talk features customer use cases starting from design to final operation, the underlying technology, and results.