Biologics PBPK model builder for Matlab SimBiology
Two-pore physiologically-based pharmacokinetics (PBPK) for biologics describes the tissue distribution and elimination kinetics of soluble proteins as a function of their hydrodynamic radius and the physiological properties of the organs.
PBPKassembler is a a collection of scripts that allows rapidly to build and debug highly customizable cross-modality/cross-species biologics PBPK models for SimBiology.
Cite As
Armin Sepp (2023). Biologics PBPK model builder for Matlab SimBiology (/matlabcentral/fileexchange/82144-biologics-pbpk-model-builder-for-matlab-simbiology), MATLAB Central File Exchange. Retrieved .
Armin Sepp, Mats Bergström & Marie Davies (2020) Cross-species/cross-modality physiologically based pharmacokinetics for biologics: 89Zr-labelled albumin-binding domain antibody GSK3128349 in humans, mAbs, 12:1, DOI: 10.1080/19420862.2020.1832861 Sepp, A., et al. (2019). "Computer-assembled cross-species/cross-modalities two-pore physiologically based pharmacokinetic model for biologics in mice and rats." Journal of Pharmacokinetics and Pharmacodynamics 46(4): 339-359. https://doi.org/10.1007/s10928-019-09640-9
MATLAB Release Compatibility
Platform Compatibility
Windows macOS LinuxTags
Acknowledgements
Inspired: Biologics PBPK model builder for Matlab SimBiology
Communities
Community Treasure Hunt
Find the treasures in MATLAB Central and discover how the community can help you!
Start Hunting!Discover Live Editor
Create scripts with code, output, and formatted text in a single executable document.
PBPKcompiler_v5.0
Version | Published | Release Notes | |
---|---|---|---|
5.0.0 |